- Industria: Government; Health care
- Number of terms: 6957
- Number of blossaries: 0
- Company Profile:
The National Cancer Institute (NCI) is part of the National Institutes of Health (NIH), which is one of 11 agencies that compose the Department of Health and Human Services (HHS). The NCI, established under the National Cancer Institute Act of 1937, is the Federal Government's principal agency for ...
Autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting the CD19 antigen, with potential immunotherapeutic activity. The CAR consists of a single chain Fv of anti-CD19 IgG1 coupled with an intracellular signaling region of the zeta-chain of the TCR/CD3 complex (CD3 zeta). Autologous EBV-CTL CD19CAR zeta directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.
Industry:Pharmaceutical
Autologous human cytomegalovirus (CMV)-specific human cytotoxic T lymphocytes (CTLs) transduced with a retroviral vector encoding a human anti-HER2 (epidermal growth factor receptor 2) chimeric T cell receptor (CAR) gene with potential immunostimulatory and antineoplastic activities. Autologous CTLs from a patient with HER2- and CMV-positive glioblastoma multiforme (GBM) are genetically modified to express CAR gene specific for HER2 on their cell surfaces. After expansion in culture and reintroduction into the patient, the anti-HER2-CAR autologous CMV-specific CTLs bind to HER2 antigen on tumor cell surfaces; subsequently, HER2-positive tumor cells and stem cells may be lysed. HER2 (ErbB2), a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis. CMV is present in the majority of GBM tumors.
Industry:Pharmaceutical
Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding an anti-Her-2 (epidermal growth factor receptor 2) chimeric T cell receptor (chimeric antigen receptor or CAR) gene with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with Her-2-positive cancer are pulsed with a retroviral vector that encodes the CAR gene specific for Her-2. After expansion in culture and reintroduction into the patient, anti-Her-2-CAR retroviral vector-transduced autologous peripheral blood lymphocytes, expressing anti-Her-2-CAR on their cell surfaces, bind to Her-2 antigen on tumor cell surfaces; subsequently, Her-2-expressing tumor cells may be lysed. Her-2 (ErbB-2), a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to the EGFR superfamily and plays key roles in tumor cell proliferation and tumor angiogenesis.
Industry:Pharmaceutical
Autologous human peripheral blood lymphocytes (PBLs), transduced with a retroviral vector encoding both the alpha and beta chains of a T cell receptor (TCR) specific for the carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, anti-CEA TCR retroviral vector-transduced autologous lymphocytes bind to tumor cells expressing CEA, which may result in cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. The tumor-associated antigen (TAA) CEA is overexpressed by a variety of cancer cell types, including those of the gastrointestinal tract, lung , and breast.
Industry:Pharmaceutical
Un benzoquinone natural important în transportul de electroni în membrane mitocondriale. Coenzima Q funcţionează ca un antioxidant endogen; deficienţe de această enzimă au fost observate la pacienţii cu mai multe tipuri de cancer şi limitat de studii au sugerat că coenzima-Q poate induce tumora regresie la pacienţii cu cancer de sân. Acest agent poate avea efecte cheratinei.
Industry:Pharmaceutical
Un antioxidant natural liposolubile cu potenţială activitate chemopreventive. Vitamina E amelioreaza radicalilor liberi deteriorarea membranelor biologice, protejarea acizi graşi polinesaturaţi (PUFA) din membrana fosfolipidelor, circulă lipoproteine. Peroxyl radicalilor 1000-fold reactioneaza mai repede cu vitamina E decât cu PUFA. În cazul oxigen radical liber-mediată stocare tumorigenesis, vitamina E poate fi chemopreventive.
Industry:Pharmaceutical
Un dérivé de la quinolone avec activité antinéoplasique potentielle. Semaxanib inhibe réversiblement ATP binding pour le domaine tyrosine kinase du récepteur 2 de facteur de croissance endothélial vasculaire (VEGFR2), qui peut-être inhiber la prolifération et la migration des cellules endothéliales VEGF stimulée et réduire la microcirculation de la tumeur. Cet agent inhibe aussi la phosphorylation de la cellules souches facteur du récepteur tyrosine kinase c-kit, souvent exprimé dans les cellules de la leucémie myéloïde aiguë.
Industry:Pharmaceutical
Un analogue de la quinoléine-3-carboxamide linomide avec anti-angiogéniques et le potentiel des activités antinéoplasiques. Tasquinimod a été montré pour réduire la densité des vaisseaux sanguins, mais on ne connaît pas le mécanisme d'action exact. Cet agent a également été montré pour augmenter les effets anticancéreux de docetaxel et androgène ablation dans un modèle murin de cancer de la prostate cancer de la prostate humain xénogreffes.
Industry:Pharmaceutical
Un alcaloïde de la quinidine isolé de l'écorce de quinquina. La quinine a plusieurs mécanismes d'action, y compris la réduction du métabolisme de l'apport et les glucides d'oxygène ; perturbation de la réplication de l'ADN et de la transcription par l'intercalation d'ADN ; et la réduction de l'excitabilité des fibres musculaires par altération de la distribution de calcium. Cet agent inhibe également la pompe à efflux drogue P-glycoprotéine qui est surexprimée dans les tumeurs résistantes à plusieurs médicaments et peut améliorer l'efficacité de certains agents antinéoplasiques.
Industry:Pharmaceutical
Un nucléoside de pyrimidine qui se compose de la thymine base de pyrimidine attaché à du sucre désoxyribose. Comme constituant de l'ADN, thymidine s'apparie avec l'adénine dans la double hélice d'ADN.
Industry:Pharmaceutical
